Engineering disease models to study host-microbe interactions
In the Porras Tissue-Microbe Interactions Lab, we study interactions between humans and microorganisms that drive tissue remodeling.
Under the leadership of Dr. Ana Maria Porras, our lab is dedicated to unraveling the complex mechanisms by which microbes regulate human health and disease. We seek to understand how microorganisms mediate host extracellular matrix remodeling, particularly in the contexts of the microbiome and tropical parasitic diseases. Additionally, we are especially interested in human-microbe relationships that have significant implications for populations in the Global South.
We use a multidisciplinary strategy to explore the relationships between microorganisms and human tissues.
First, we use microscopy, bioinformatics, and microbiology tools to characterize the tissue remodeling that occurs as a direct result of human-microbe interactions. We then use that information to design biomaterials-based models that mimic the properties of healthy and diseased tissues. These engineered tissue platforms allow us to identify the mechanisms through which “beneficial” and pathogenic microorganisms drive disease processes in the human host.
We strive to promote scientifically inclusive environments that incorporate diverse perspectives from diverse team members and collaborators.
We approach research questions with an open mind, willing to dive into unexplored areas, and seeking to increase participation in the scientific process - locally and globally. We also believe in the power of art and science communication to engage communities and ignite curiosity.
